MATLAB PROJECT
A
Single Sensor Dual-Modality Photoacoustic Fusion Imaging for Compensation of
Light Fluence Variation
Abstract:
Objective: A photoacoustic signal is proportional to the product of the
optical absorption coefficient and the local light fluence; quantitative
photoacoustic measurements of the optical absorption coefficients, therefore,
require an accurate compensation of optical fluence variation. Usually, an
additional diffuse optical tomography is incorporated to estimate the light
fluence variation, but it is often troubled with the bulky measurement system.
On this note, we present a dual-modality photoacoustic fusion imaging method
that is implemented with a normal photoacoustic imaging (PAI) device. Methods:
A single piezoelectric transducer is employed to receive the photoacoustic
waves and passive ultrasound (PU) waves simultaneously. Since the PU wave is
generated by the backscattering and diffuse reflection photons, it has the
capacity to facilitate diffuse reflectance (DR) imaging. We merged
photoacoustic and DR imaging based on their dual-modality with a compensation
of the optical fluence variation. Results: The absorption coefficient
differences caused by the light fluence variation are reduced more than half
with the proposed method, when comparing to the pure photoacoustic imaging.
Conclusion: The dual-modality photoacoustic fusion imaging is able to correct
the PAI errors caused by the optical fluence variation. Significance: The
proposed method can be widely accepted by different PAI applications to
compensate the light fluence variations without any additional required
element.
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